Constraint-Based Modeling and Simulation of Cell Populations
نویسندگان
چکیده
The intratumor heterogeneity has been recognized to characterize cancer cells impairing the efficacy of cancer treatments. We here propose an extension of constraint-based modeling approach in order to simulate metabolism of cell populations with the aim to provide a more complete characterization of these systems, especially focusing on the relationships among their components. We tested our methodology by using a toy-model and taking into account the main metabolic pathways involved in cancer metabolic rewiring. This toy-model is used as “individual” to construct a “population model” characterized by multiple interacting individuals, all having the same topology and stoichiometry, and sharing the same nutrients supply. We observed that, in our population, cancer cells cooperate with each other to reach a common objective, but without necessarily having the same metabolic traits. We also noticed that the heterogeneity emerging from the population model is due to the mismatch between the objective of the individual members and the objective of the entire population.
منابع مشابه
Three-dimensional modeling of transport phenomena in a planar anode-supported solid oxide fuel cell
In this article three dimensional modeling of a planar solid oxide fuel cell (SOFC) was investigated. The main objective was to attain the optimized cell operation. SOFC operation simulation involves a large number of parameters, complicated equations, (mostly partial differential equations), and a sophisticated simulation technique; hence, a finite element method (FEM) multiphysics approach ...
متن کاملDynamics and Regulation of Locomotion of a Human Swing Leg as a Double-Pendulum Considering Self-Impact Joint Constraint
Background:Despite some successful dynamic simulation of self-impact double pendulum (SIDP)-as humanoid robots legs or arms- studies, there is limited information available about the control of one leg locomotion.Objective :The main goal of this research is to improve the reliability of the mammalians leg locomotion and building more elaborated models close to the natural movements, by modelin...
متن کاملA Two-Phase Simulation-Based Optimization of Hauling System in Open-Pit Mine
One of the key issues in mining is the hauling system. Truck and shovels are the most widely used transportation equipment in mines. In this paper, a two-phase simulation-based optimization is presented to maximize utilization of hauling system in the largest Iranian open-pit copper mine. In the first phase, The OptQuest for Arena software package was used to solve the optimization problem to p...
متن کاملA Robust Adaptive Observer-Based Time Varying Fault Estimation
This paper presents a new observer design methodology for a time varying actuator fault estimation. A new linear matrix inequality (LMI) design algorithm is developed to tackle the limitations (e.g. equality constraint and robustness problems) of the well known so called fast adaptive fault estimation observer (FAFE). The FAFE is capable of estimating a wide range of time-varying actuator fault...
متن کاملKinematic and Dynamic Analysis of Tripteron, an Over-constrained 3-DOF Translational Parallel Manipulator, Through Newton-Euler Approach
In this research, as the main contribution, a comprehensive study is carried out on the mathematical modeling and analysis of the inverse kinematics and dynamics of an over-constraint three translational degree-of-freedom parallel manipulator. Due to the inconsistency between the number of equations and unknowns, the problem of obtaining the constraint forces and torques of an over-constraint m...
متن کاملModeling of Multi-population Microbial Fuel and Electrolysis Cells Based on the Bioanode Potential Conditions
Microbial fuel cell and microbial electrolysis cell are two major types of microbial electrochemical cells. In the present study, we governed modeling of these systems by concentrating on the simulation of bioelectrochemical reactions in both biofilm and anolyte and considering the effect of pH on the microbial growth. The simulation of microbial fuel and electrolysis cells can be described by ...
متن کامل